Version 5.4
Mus musculus Protein: Krt75
Summary
InnateDB Protein IDBP-186279.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt75
Protein Name keratin 75
Synonyms 4732468K03Rik; AA589387; K6hf; Krt2-6hf; Krtcap1;
Species Mus musculus
Ensembl Protein ENSMUSP00000036246
InnateDB Gene IDBG-186277 (Krt75)
Protein Structure
UniProt Annotation
Function Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in the companion layer and upper germinative matrix region of the hair follicle and the medulla of the hair shaft. Also expressed in epithelia of the nail bed and fungiform papillae of dorsal tongue epithelium (at protein level). {ECO:0000269PubMed:11489919, ECO:0000269PubMed:14675170, ECO:0000269PubMed:17851587}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1923500
InterPro IPR001664 Intermediate filament protein
IPR003054 Keratin, type II
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01276
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGZ7
PhosphoSite PhosphoSite-Q8BGZ7
TrEMBL Q99MH7
UniProt Splice Variant
Entrez Gene 109052
UniGene Mm.106868
RefSeq NP_579935
MGI ID
MGI Symbol Krt75
OMIM
CCDS CCDS27856
HPRD
IMGT
EMBL AF343088 AK028972 AK037233 AK076367 BC137935 BC137936
GenPept AAI37936 AAI37937 AAK17206 BAC26221 BAC29769 BAC36315

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca