Version 5.4
Mus musculus Protein: Clec4d
Summary
InnateDB Protein IDBP-186347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clec4d
Protein Name C-type lectin domain family 4, member d
Synonyms Clecsf8; mcl; Mpcl;
Species Mus musculus
Ensembl Protein ENSMUSP00000032240
InnateDB Gene IDBG-186345 (Clec4d)
Protein Structure
UniProt Annotation
Function Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in the macrophage populations of bone marrow, spleen, lung and lymph nodes. {ECO:0000269PubMed:9660840}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1298389
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z2H6
PhosphoSite PhosphoSite-Q9Z2H6
TrEMBL Q4KL29
UniProt Splice Variant
Entrez Gene 17474
UniGene Mm.441101
RefSeq NP_034949
MGI ID
MGI Symbol Clec4d
OMIM
CCDS CCDS20513
HPRD
IMGT
EMBL AF061272 AK089500 AK150926 AK171409 BC099471 CH466523
GenPept AAD05125 AAH99471 BAC40905 BAE29964 BAE42436 EDK99714

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca