InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myocd

Summary

InnateDB Protein

IDBP-186356.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myocd

Protein Name

myocardin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099695

InnateDB Gene

IDBG-186354 (Myocd)

Protein Structure

UniProt Annotation

Function

Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters. {ECO:0000269PubMed:11439182, ECO:0000269PubMed:12640126, ECO:0000269PubMed:12663482, ECO:0000269PubMed:16818234, ECO:0000269PubMed:20385216}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:11439182, ECO:0000269PubMed:15601857}. Note=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei.

Disease Associations

Tissue Specificity

Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder and uterus. Isoform 1 and isoform 3 are predominantly expressed in cardiac muscle whereas isoform 4 and isoform 5 are predominantly expressed in SMC-rich tissues. Isoform 3 is the most abundant isoform in the heart from embryo to adult. {ECO:0000269PubMed:11439182, ECO:0000269PubMed:12640126, ECO:0000269PubMed:12663482, ECO:0000269PubMed:14645532, ECO:0000269PubMed:20385216}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676	nucleic acid binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0035035	histone acetyltransferase binding
GO:0042826	histone deacetylase binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001560	regulation of cell growth by extracellular stimulus
GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0003231	cardiac ventricle development
GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0010832	negative regulation of myotube differentiation
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0035065	regulation of histone acetylation
GO:0035733	hepatic stellate cell activation
GO:0042692	muscle cell differentiation
GO:0043388	positive regulation of DNA binding
GO:0043954	cellular component maintenance
GO:0045661	regulation of myoblast differentiation
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045987	positive regulation of smooth muscle contraction
GO:0048286	lung alveolus development
GO:0048565	digestive tract development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051145	smooth muscle cell differentiation
GO:0051150	regulation of smooth muscle cell differentiation
GO:0051152	positive regulation of smooth muscle cell differentiation
GO:0055007	cardiac muscle cell differentiation
GO:0055012	ventricular cardiac muscle cell differentiation
GO:0060065	uterus development
GO:0060157	urinary bladder development
GO:0061049	cell growth involved in cardiac muscle cell development
GO:0071363	cellular response to growth factor stimulus
GO:0071456	cellular response to hypoxia
GO:0097070	ductus arteriosus closure
GO:1900222	negative regulation of beta-amyloid clearance
GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2000724	positive regulation of cardiac vascular smooth muscle cell differentiation
GO:2000727	positive regulation of cardiac muscle cell differentiation
GO:2001015	negative regulation of skeletal muscle cell differentiation