InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rragc

Summary

InnateDB Protein

IDBP-186413.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rragc

Protein Name

Ras-related GTP binding C

Synonyms

AU041672; Gtr2; RAGC; TIB929; YGR163W;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030399

InnateDB Gene

IDBG-186411 (Rragc)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Lysosome {ECO:0000250}. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed most abundantly in kidney. Moderately expressed in brain, ovary, and testis, and detected at lower levels in heart, liver, and muscle. Not detected in lung, spleen, and small intestine. Widely expressed in tumor cells, with expression being specifically up-regulated in highly metastatic cells. {ECO:0000269PubMed:10660099}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006184	GTP catabolic process
GO:0032008	positive regulation of TOR signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome

Protein Structure and Domains

PDB ID

MGI:1858751

InterPro

IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR019009 Signal recognition particle receptor, beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00025
PF04670
PF09439

PRINTS

PR00328

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99K70