InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Saa2

Summary

InnateDB Protein

IDBP-186448.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Saa2

Protein Name

serum amyloid A 2

Synonyms

AW111173; Saa-2; Saa1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075365

InnateDB Gene

IDBG-186446 (Saa2)

Protein Structure

UniProt Annotation

Function

Major acute phase reactant. Apolipoprotein of the HDL complex.

Subcellular Localization

Secreted.

Disease Associations

Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

Tissue Specificity

Expressed by the liver; secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006953	acute-phase response
GO:0035634	response to stilbenoid

Cellular Component

GO:0005576	extracellular region
GO:0034364	high-density lipoprotein particle

Protein Structure and Domains

PDB ID

MGI:98222

InterPro

IPR000096 Serum amyloid A protein

PFAM

PF00277

PRINTS

PR00306

PIRSF

PIRSF002472

SMART

SM00197

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05367

PhosphoSite

PhosphoSite-

TrEMBL

Q8R4W4

UniProt Splice Variant

Entrez Gene

20209

UniGene

RefSeq

NP_035444

MGI ID

MGI Symbol

Saa2

OMIM

CCDS

CCDS21285

HPRD

IMGT

EMBL

AF354287 M11130 M13522 M17791

GenPept

AAA40085 AAA40086 AAA40087 AAL83956