Version 5.4
Mus musculus Protein: Sf3a3
Summary
InnateDB Protein IDBP-186658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sf3a3
Protein Name splicing factor 3a, subunit 3
Synonyms 4930512K19Rik; 60kDa;
Species Mus musculus
Ensembl Protein ENSMUSP00000030734
InnateDB Gene IDBG-186656 (Sf3a3)
Protein Structure
UniProt Annotation
Function Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00130}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:1922312
InterPro IPR000690 Zinc finger, C2H2-type matrin
IPR021966 Splicing factor SF3a60 binding domain
IPR024598 Domain of unknown function DUF3449
PFAM PF12108
PF11931
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D554
PhosphoSite PhosphoSite-Q9D554
TrEMBL Q58E59
UniProt Splice Variant
Entrez Gene 75062
UniGene Mm.25779
RefSeq NP_083433
MGI ID
MGI Symbol Sf3a3
OMIM
CCDS CCDS38875
HPRD
IMGT
EMBL AK015776 AK030743 AK150733 AK151141 AK151382 AK161646 AK168966 AK169324 BC009141 BC092058
GenPept AAH09141 AAH92058 BAB29971 BAC27111 BAE29808 BAE30148 BAE30354 BAE36510 BAE40771 BAE41078

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca