Version 5.4
Mus musculus Protein: Psma5
Summary
InnateDB Protein IDBP-186690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psma5
Protein Name proteasome (prosome, macropain) subunit, alpha type 5
Synonyms ZETA;
Species Mus musculus
Ensembl Protein ENSMUSP00000088057
InnateDB Gene IDBG-186688 (Psma5)
Protein Structure
UniProt Annotation
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. {ECO:0000269PubMed:22341445}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 82 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex
Protein Structure and Domains
PDB ID MGI:1347009
InterPro IPR000426 Proteasome alpha-subunit, N-terminal domain
IPR001353 Proteasome, subunit alpha/beta
IPR029055 Nucleophile aminohydrolases, N-terminal
PFAM PF10584
PF00227
PRINTS
PIRSF
SMART SM00948
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z2U1
PhosphoSite PhosphoSite-Q9Z2U1
TrEMBL Q3UPK6
UniProt Splice Variant
Entrez Gene 26442
UniGene Mm.412731
RefSeq NP_036097
MGI ID 3UNH
MGI Symbol Psma5
OMIM
CCDS CCDS17755
HPRD
IMGT
EMBL AF019661 AK143468 AK160550 AK161680 BC010709 BC083342 BC108368 CH466607
GenPept AAC69149 AAH10709 AAH83342 AAI08369 BAE25389 BAE35866 BAE36528 EDL01960

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca