InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMIGD2

Summary

InnateDB Protein

IDBP-18674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMIGD2

Protein Name

transmembrane and immunoglobulin domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000301272

InnateDB Gene

IDBG-18672 (TMIGD2)

Protein Structure

UniProt Annotation

Function

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T- cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269PubMed:22419821, ECO:0000269PubMed:23784006}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22419821}; Single-pass type I membrane protein {ECO:0000269PubMed:22419821}.

Disease Associations

Tissue Specificity

Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double- negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells(at protein level). Not detected on B-cells(at protein level). Expressed in tonsils (at protein level). {ECO:0000269PubMed:22419821, ECO:0000269PubMed:23784006}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015026	coreceptor activity

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0007165	signal transduction
GO:0031295	T cell costimulation
GO:0042104	positive regulation of activated T cell proliferation