Version 5.4
Mus musculus Protein: Dlk2
Summary
InnateDB Protein IDBP-186773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlk2
Protein Name delta-like 2 homolog (Drosophila)
Synonyms AI413481; DLK-2; Egfl9;
Species Mus musculus
Ensembl Protein ENSMUSP00000058470
InnateDB Gene IDBG-186771 (Dlk2)
Protein Structure
UniProt Annotation
Function Regulates adipogenesis. {ECO:0000269PubMed:17320102}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in a number of tissues including lung, brain, adrenal gland, testis, adult liver, placenta, ovary and thymus. Not detected in fetal liver or in adult spleen, muscle and heart. {ECO:0000269PubMed:17320102}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0045598 regulation of fat cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2146838
InterPro IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR013111 EGF-like domain, extracellular
PFAM PF00008
PF07645
PF07974
PRINTS
PIRSF
SMART SM00181
SM00179
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K1E3
PhosphoSite PhosphoSite-Q8K1E3
TrEMBL
UniProt Splice Variant
Entrez Gene 106565
UniGene Mm.23633
RefSeq NP_997549
MGI ID
MGI Symbol Dlk2
OMIM
CCDS
HPRD
IMGT
EMBL AB011019 BC019431 BC118057 BC122518 BY271273 CH466559 CT009572 FM180474
GenPept AAI18058 AAI22519 BAA88686 CAQ86598 EDL23496

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca