InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tsn

Summary

InnateDB Protein

IDBP-186781.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tsn

Protein Name

translin

Synonyms

2610034C24Rik; AU040286; C3PO; TB-RBP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027623

InnateDB Gene

IDBG-186779 (Tsn)

Protein Structure

UniProt Annotation

Function

DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. {ECO:0000269PubMed:15491149}.Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand. {ECO:0000269PubMed:15491149}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding