InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clstn3

Summary

InnateDB Protein

IDBP-186877.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clstn3

Protein Name

calsyntenin 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008297

InnateDB Gene

IDBG-186875 (Clstn3)

Protein Structure

UniProt Annotation

Function

May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269PubMed:12498782}. Golgi apparatus membrane {ECO:0000269PubMed:12498782}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.

Disease Associations

Tissue Specificity

Restricted to the brain. In the cerebral cortex, found in the somas and neuropil of all layers. Expressed at highest levels in neurons of cortical layer 5 and, at lower levels, in neurons of the upper layers. Highly expressed in Purkinje cells. Also found in a few scattered interneurons throughout the granule cell layer and occasionally in neurons in the molecular layer (at protein level). In all layers, high levels in a subpopulation of presumptive GABAergic neurons (based on morphology). {ECO:0000269PubMed:12498782}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0008150	biological_process

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome