Version 5.4
Mus musculus Protein: C1rl
Summary
InnateDB Protein IDBP-186990.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1rl
Protein Name complement component 1, r subcomponent-like
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000042883
InnateDB Gene IDBG-186988 (C1rl)
Protein Structure
UniProt Annotation
Function Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in liver (at protein level).
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006958 complement activation, classical pathway
GO:0045087 innate immune response
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2660692
InterPro IPR000436 Sushi/SCR/CCP
IPR000859 CUB domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00084
PF00431
PF00089
PRINTS PR00722
PIRSF
SMART SM00032
SM00042
SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UZ09
PhosphoSite PhosphoSite-Q3UZ09
TrEMBL
UniProt Splice Variant
Entrez Gene 232371
UniGene Mm.132974
RefSeq NP_851989
MGI ID
MGI Symbol C1rl
OMIM
CCDS CCDS20520
HPRD
IMGT
EMBL AF456427 AF456428 AK133495 AK134207 BC070472
GenPept AAH70472 AAP41416 AAP41417 BAE21686 BAE22052

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca