InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsf4

Summary

InnateDB Protein

IDBP-186993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsf4

Protein Name

heat shock transcription factor 4

Synonyms

HSF 4; HSTF 4; HSTF4; ldis1; mHSF4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048904

InnateDB Gene

IDBG-186991 (Hsf4)

Protein Structure

UniProt Annotation

Function

DNA-binding protein that specifically binds heat shock promoter elements (HSE). The HSF4A isoform represses transcription while the HSF4B isoform activates transcription.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Preferentially expressed in brain and lung. Also found in the eye. Slightly detected in liver and skeletal muscle. Isoform B is the major species in various tissues. {ECO:0000269PubMed:16581800}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0019903	protein phosphatase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001654	eye development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006950	response to stress
GO:0008284	positive regulation of cell proliferation
GO:0033169	histone H3-K9 demethylation
GO:0043010	camera-type eye development
GO:0045597	positive regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0070207	protein homotrimerization