InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: C1ra

Summary

InnateDB Protein

IDBP-187032.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C1ra

Protein Name

complement component 1, r subcomponent A

Synonyms

AI132558; C1r; mC1rA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063707

InnateDB Gene

IDBG-187030 (C1ra)

Protein Structure

UniProt Annotation

Function

C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0006958	complement activation, classical pathway
GO:0045087	innate immune response

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

MGI:1355313

InterPro

IPR000436 Sushi/SCR/CCP
IPR000742 Epidermal growth factor-like domain
IPR000859 CUB domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00084
PF00008
PF00431
PF00089
PF07645

PRINTS

PR00722

PIRSF

SMART

SM00032
SM00181
SM00042
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt