InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tsg101

Summary

InnateDB Protein

IDBP-187083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tsg101

Protein Name

tumor susceptibility gene 101

Synonyms

AI255943; CC2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014546

InnateDB Gene

IDBG-187081 (Tsg101)

Protein Structure

UniProt Annotation

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Mainly cytoplasmic. Membrane- associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Higher expression in brain and mammary gland. Lower expression in liver and tumoral tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 127 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	127 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006464	cellular protein modification process
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0015031	protein transport
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046755	non-lytic virus budding
GO:0051301	cell division

Cellular Component

GO:0000813	ESCRT I complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome