Version 5.4
| Mus musculus Protein: Slc22a7 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-187140.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Slc22a7 | ||||||||
| Protein Name | solute carrier family 22 (organic anion transporter), member 7 | ||||||||
| Synonyms | NLT; OAT2; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000084234 | ||||||||
| InnateDB Gene | IDBG-187138 (Slc22a7) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Mediates sodium-independent multispecific organic anion transport. High affinity transport of glutarate and prostaglandin E2 in a sodium-independent manner. Mediates also the uptake of alpha-ketoglutarate, p-aminohippuric acid, methotrexate, ochratoxin A, valproate, allopurinol and bumetanide. {ECO:0000269PubMed:16256982}. | ||||||||
| Subcellular Localization | Basolateral cell membrane; Multi-pass membrane protein. Note=Apical side of the renal tubule. {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Abundant expression in male and female kidney and also in female liver. {ECO:0000269PubMed:12065749}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1859559 | ||||||||
| InterPro |
IPR004749
Organic cation transport protein IPR005828 General substrate transporter IPR011701 Major facilitator superfamily IPR016196 Major facilitator superfamily domain, general substrate transporter IPR020846 Major facilitator superfamily domain |
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| PFAM |
PF00083
PF07690 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q91WU2 | ||||||||
| PhosphoSite | PhosphoSite-Q91WU2 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 108114 | ||||||||
| UniGene | Mm.387538 | ||||||||
| RefSeq | NP_659105 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Slc22a7 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS28829 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB069965 AK082865 AK143949 BC013474 BC024119 BC025813 BC026597 BC026598 | ||||||||
| GenPept | AAH13474 AAH24119 AAH25813 AAH26597 AAH26598 BAC02736 BAC38659 BAE25625 | ||||||||