InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttbk1

Summary

InnateDB Protein

IDBP-187187.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttbk1

Protein Name

tau tubulin kinase 1

Synonyms

AU017937; AW048023; C330008L01Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044580

InnateDB Gene

IDBG-187185 (Ttbk1)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the brain. Strong expression in the cortical layers, the CA1 layers of the hippocampus and the granular layer of the cerebellum. Also expressed in the large cortical pyramidal cells in the temporal cortex, the CA1 pyramidal neurons and the cerebellum granular neurons. {ECO:0000269PubMed:16923168}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0008150	biological_process
GO:0021762	substantia nigra development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

MGI:2147036

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt