Version 5.4
Mus musculus Protein: Tfcp2l1
Summary
InnateDB Protein IDBP-187211.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfcp2l1
Protein Name transcription factor CP2-like 1
Synonyms 1810030F05Rik; 4932442M07Rik; AA575098; Cp2l1; Crtr-1; D930018N21Rik; LBP-9; Tcfcp2l1;
Species Mus musculus
Ensembl Protein ENSMUSP00000027629
InnateDB Gene IDBG-187207 (Tfcp2l1)
Protein Structure
UniProt Annotation
Function Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney. {ECO:0000269PubMed:11073954, ECO:0000269PubMed:17079272}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Highly expressed in placenta, testis, small intestine, kidney and stomach. Low levels of expression in lung, mesenteric lymph nodes, muscle, ovary, and thymus. No expression was detected in brain, heart, liver, and spleen. Expressed in eccrine glands in the palm. {ECO:0000269PubMed:11073954, ECO:0000269PubMed:17079272}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 99 [view]
Protein-Protein 93 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0002070 epithelial cell maturation
GO:0006351 transcription, DNA-templated
GO:0007028 cytoplasm organization
GO:0007431 salivary gland development
GO:0008340 determination of adult lifespan
GO:0045927 positive regulation of growth
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2444691
InterPro IPR007604 CP2 transcription factor
IPR013761 Sterile alpha motif/pointed domain
PFAM PF04516
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UNW5
PhosphoSite PhosphoSite-Q3UNW5
TrEMBL
UniProt Splice Variant
Entrez Gene 81879
UniGene Mm.422143
RefSeq NP_076244
MGI ID
MGI Symbol Tfcp2l1
OMIM
CCDS CCDS35691
HPRD
IMGT
EMBL AC109271 AC109294 AF311309 AK143960 BC116663 CH466520
GenPept AAI16664 AAK01150 BAE25632 EDL39825

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca