Version 5.4
Mus musculus Protein: Col12a1
Summary
InnateDB Protein IDBP-187278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col12a1
Protein Name collagen, type XII, alpha 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000071662
InnateDB Gene IDBG-187276 (Col12a1)
Protein Structure
UniProt Annotation
Function Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Highest expression in tendons, perichondrium, skin, cornea, sclera, blood vessels, and periosteum.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:88448
InterPro IPR001791 Laminin G domain
IPR002035 von Willebrand factor, type A
IPR003961 Fibronectin, type III
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00054
PF02210
PF00092
PF00041
PF01108
PF01391
PRINTS
PIRSF
SMART SM00210
SM00282
SM00327
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60847
PhosphoSite PhosphoSite-Q60847
TrEMBL Q3TNZ7
UniProt Splice Variant
Entrez Gene 12816
UniGene Mm.461533
RefSeq NP_001277237
MGI ID
MGI Symbol Col12a1
OMIM
CCDS CCDS72284
HPRD
IMGT
EMBL AC157477 AC166055 AK164846 U25652 U57095
GenPept AAA99719 AAB07047 BAE37940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca