InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnl2

Summary

InnateDB Protein

IDBP-187293.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnl2

Protein Name

guanine nucleotide binding protein-like 2 (nucleolar)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030684

InnateDB Gene

IDBG-187291 (Gnl2)

Protein Structure

UniProt Annotation

Function

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0015684	ferrous iron transport
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005730	nucleolus
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2385207

InterPro

IPR006073 GTP binding domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR012971 Nucleolar GTP-binding protein 2, N-terminal domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01926
PF02421
PF08153

PRINTS

PR00326

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99LH1