InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hs6st3

Summary

InnateDB Protein

IDBP-187308.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hs6st3

Protein Name

heparan sulfate 6-O-sulfotransferase 3

Synonyms

6OST3; HS6ST-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070394

InnateDB Gene

IDBG-187306 (Hs6st3)

Protein Structure

UniProt Annotation

Function

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:10644753}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0017095	heparan sulfate 6-O-sulfotransferase activity

Biological Process

GO:0015015

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1354960

InterPro

IPR005331 Sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03567

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QYK4

PhosphoSite

PhosphoSite-

TrEMBL

Q149R8

UniProt Splice Variant

Entrez Gene

50787

UniGene

RefSeq

NP_056635

MGI ID

MGI Symbol

Hs6st3

OMIM

CCDS

CCDS27339

HPRD

IMGT

EMBL

AB024567 BC117529 BC118035

GenPept

AAI17530 AAI18036 BAA89249