InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Inhbb

Summary

InnateDB Protein

IDBP-187386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Inhbb

Protein Name

inhibin beta-B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044918

InnateDB Gene

IDBG-187384 (Inhbb)

Protein Structure

UniProt Annotation

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Uterus, testis, ovary, lung, kidney, brain, CJ7 embryonic stem cells, and possibly in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001654	eye development
GO:0009267	cellular response to starvation
GO:0009612	response to mechanical stimulus
GO:0032869	cellular response to insulin stimulus
GO:0032924	activin receptor signaling pathway
GO:0040007	growth
GO:0044320	cellular response to leptin stimulus
GO:0045444	fat cell differentiation
GO:0046676	negative regulation of insulin secretion
GO:0046881	positive regulation of follicle-stimulating hormone secretion
GO:0046882	negative regulation of follicle-stimulating hormone secretion
GO:0048178	negative regulation of hepatocyte growth factor biosynthetic process
GO:0048599	oocyte development
GO:0060279	positive regulation of ovulation
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:96571

InterPro

IPR000381 Inhibin, beta B subunit
IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00671
PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt