InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snip1

Summary

InnateDB Protein

IDBP-187424.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snip1

Protein Name

Smad nuclear interacting protein 1

Synonyms

2410133M08Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060721

InnateDB Gene

IDBG-187422 (Snip1)

Protein Structure

UniProt Annotation

Function

Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0035196	production of miRNAs involved in gene silencing by miRNA