InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epb4.1l5

Summary

InnateDB Protein

IDBP-187448.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epb4.1l5

Protein Name

erythrocyte protein band 4.1-like 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058966

InnateDB Gene

IDBG-187446 (Epb4.1l5)

Protein Structure

UniProt Annotation

Function

May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17920587}. Cell junction, adherens junction {ECO:0000269PubMed:17920587}. Note=Associated with the plasma membrane. During embryonic development, tends to be associated with the basolateral side of the plasma membrane in various tissues. In the adult kidney, found at the basolateral and apical sides of the tubules. In the adult retina, colocalizes with CTNNB1, an adherens junction marker.

Disease Associations

Tissue Specificity

In the retina, expressed at the region of the outer limiting membrane, as well as in the retinal pigment epithelium, outer nuclear and outer plexiform layers. Also detected in the inner segments (at protein level). Expressed in the kidney (at protein level). {ECO:0000269PubMed:17920587}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000904	cell morphogenesis involved in differentiation
GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0001839	neural plate morphogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0003382	epithelial cell morphogenesis
GO:0003383	apical constriction
GO:0006931	substrate-dependent cell migration, cell attachment to substrate
GO:0007398	ectoderm development
GO:0007492	endoderm development
GO:0007498	mesoderm development
GO:0007509	mesoderm migration involved in gastrulation
GO:0009826	unidimensional cell growth
GO:0010608	posttranscriptional regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0022408	negative regulation of cell-cell adhesion
GO:0030036	actin cytoskeleton organization
GO:0031032	actomyosin structure organization
GO:0032091	negative regulation of protein binding
GO:0032092	positive regulation of protein binding
GO:0032525	somite rostral/caudal axis specification
GO:0048318	axial mesoderm development
GO:0048319	axial mesoderm morphogenesis
GO:0048339	paraxial mesoderm development
GO:0048617	embryonic foregut morphogenesis
GO:0051894	positive regulation of focal adhesion assembly
GO:0070201	regulation of establishment of protein localization
GO:0070986	left/right axis specification
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0019898	extrinsic component of membrane
GO:0031252	cell leading edge
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

MGI:103006

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF08736
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt