InnateDB Protein
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IDBP-187720.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atn1
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Protein Name
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atrophin 1
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Synonyms
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Atr1; atrophin-1; Drpla;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000085695
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InnateDB Gene
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IDBG-187718 (Atn1)
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Protein Structure
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Function |
Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. {ECO:0000250, ECO:0000269PubMed:16702404, ECO:0000269PubMed:19131340}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000250}. Cell junction {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells. Colocalizes with MTG8 in discrete nuclear dots (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Most abundant in the brain. {ECO:0000269PubMed:9070948}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 90 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
90 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104725
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InterPro |
IPR002951
Atrophin-like
IPR017993
Atrophin-1
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PFAM |
PF03154
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PRINTS |
PR01222
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O35126
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PhosphoSite |
PhosphoSite-O35126
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TrEMBL |
D3YYE6
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UniProt Splice Variant |
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Entrez Gene |
13498
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UniGene |
Mm.488648
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RefSeq |
NP_031907
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MGI ID |
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MGI Symbol |
Atn1
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OMIM |
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CCDS |
CCDS20526
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HPRD |
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IMGT |
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EMBL |
AC002397
AC164157
BC050920
BC053051
CH466523
D87744
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GenPept |
AAC36003
AAH50920
AAH53051
BAA13450
EDK99754
EDK99755
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