InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dusp6

Summary

InnateDB Protein

IDBP-187796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dusp6

Protein Name

dual specificity phosphatase 6

Synonyms

1300019I03Rik; MKP-3; MKP3; PYST1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020118

InnateDB Gene

IDBG-187794 (Dusp6)

Protein Structure

UniProt Annotation

Function

Inactivates MAP kinases. Has a specificity for the ERK family (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001933	negative regulation of protein phosphorylation
GO:0006470	protein dephosphorylation
GO:0009953	dorsal/ventral pattern formation
GO:0010033	response to organic substance
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0016311	dephosphorylation
GO:0030154	cell differentiation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0042493	response to drug
GO:0042663	regulation of endodermal cell fate specification
GO:0043065	positive regulation of apoptotic process
GO:0051409	response to nitrosative stress
GO:0060420	regulation of heart growth
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070848	response to growth factor

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1914853

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782
PF00581

PRINTS

PR01764

PIRSF

PIRSF000939

SMART

SM00450
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References