Version 5.4
Mus musculus Protein: Lsm10
Summary
InnateDB Protein IDBP-187819.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lsm10
Protein Name U7 snRNP-specific Sm-like protein LSM10
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000061913
InnateDB Gene IDBG-187817 (Lsm10)
Protein Structure
UniProt Annotation
Function Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017069 snRNA binding
GO:0071208 histone pre-mRNA DCP binding
Biological Process
GO:0000084 mitotic S phase
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005683 U7 snRNP
GO:0015030 Cajal body
Protein Structure and Domains
PDB ID MGI:2151045
InterPro IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain
PFAM PF01423
PRINTS
PIRSF
SMART SM00651
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8QZX5
PhosphoSite PhosphoSite-Q8QZX5
TrEMBL Q3UPL7
UniProt Splice Variant
Entrez Gene 116748
UniGene
RefSeq NP_620046
MGI ID
MGI Symbol Lsm10
OMIM
CCDS CCDS18642
HPRD
IMGT
EMBL AK143443 AL627101 BC024543 BC026476 CH466552
GenPept AAH24543 AAH26476 BAE25378 EDL30310

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca