InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SKOR1

Summary

InnateDB Protein

IDBP-18784.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKOR1

Protein Name

SKI family transcriptional corepressor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343200

InnateDB Gene

IDBG-18778 (SKOR1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Present specifically in cerebellar Purkinje cells (at protein level). {ECO:0000269PubMed:17292623}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046332	SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated