InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Soat2

Summary

InnateDB Protein

IDBP-187861.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Soat2

Protein Name

sterol O-acyltransferase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023806

InnateDB Gene

IDBG-187859 (Soat2)

Protein Structure

UniProt Annotation

Function

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0004772	sterol O-acyltransferase activity
GO:0015485	cholesterol binding
GO:0034736	cholesterol O-acyltransferase activity

Biological Process

GO:0008203	cholesterol metabolic process
GO:0033344	cholesterol efflux
GO:0034379	very-low-density lipoprotein particle assembly
GO:0034435	cholesterol esterification

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0016021	integral component of membrane