InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dbx1

Summary

InnateDB Protein

IDBP-187902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dbx1

Protein Name

developing brain homeobox 1

Synonyms

AI426026; Dbx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032717

InnateDB Gene

IDBG-187900 (Dbx1)

Protein Structure

UniProt Annotation

Function

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. {ECO:0000269PubMed:11239429}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0021521	ventral spinal cord interneuron specification