Version 5.4
Mus musculus Protein: Dbi
Summary
InnateDB Protein IDBP-187922.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dbi
Protein Name diazepam binding inhibitor
Synonyms ACBD1; Acbp; endozepine; EP;
Species Mus musculus
Ensembl Protein ENSMUSP00000027634
InnateDB Gene IDBG-187920 (Dbi)
Protein Structure
UniProt Annotation
Function Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Subcellular Localization Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Golgi localization is dependent on ligand binding. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0008289 lipid binding
Biological Process
GO:0001942 hair follicle development
GO:0006641 triglyceride metabolic process
GO:0006810 transport
GO:0043588 skin development
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:94865
InterPro IPR000582 Acyl-CoA-binding protein, ACBP
PFAM PF00887
PRINTS PR00689
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31786
PhosphoSite PhosphoSite-P31786
TrEMBL Q548W7
UniProt Splice Variant
Entrez Gene 13167
UniGene
RefSeq NP_031856
MGI ID
MGI Symbol Dbi
OMIM
CCDS CCDS15230
HPRD
IMGT
EMBL AC139867 AF220221 AK008540 AK008576 AK018720 AK020692 AK027906 AK148753 BC028874 CH466520 EF437365 X61431
GenPept AAH28874 AAL56658 ABS83527 BAB25730 BAB25755 BAB31366 BAB32175 BAC25658 BAE28656 CAA43673 EDL39802

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca