InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stxbp3a

Summary

InnateDB Protein

IDBP-187994.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stxbp3a

Protein Name

syntaxin binding protein 3A

Synonyms

Munc-18c; Stxbp3; Sxtbp3; Unc18-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099681

InnateDB Gene

IDBG-187992 (Stxbp3a)

Protein Structure

UniProt Annotation

Function

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000269PubMed:9045631}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000269PubMed:9045631}. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues tested. {ECO:0000269PubMed:8824310}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding

Biological Process

GO:0006887	exocytosis
GO:0006904	vesicle docking involved in exocytosis
GO:0007420	brain development
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016192	vesicle-mediated transport
GO:0022615	protein to membrane docking
GO:0030073	insulin secretion
GO:0032868	response to insulin