InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prmt3

Summary

InnateDB Protein

IDBP-188020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prmt3

Protein Name

protein arginine N-methyltransferase 3

Synonyms

2010005E20Rik; 2410018A17Rik; AL033309; Hrmt1l3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032715

InnateDB Gene

IDBG-188018 (Prmt3)

Protein Structure

UniProt Annotation

Function

Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016274	protein-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0046872	metal ion binding
GO:0072341	modified amino acid binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0018216	peptidyl-arginine methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0031397	negative regulation of protein ubiquitination
GO:0034969	histone arginine methylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome

Protein Structure and Domains

PDB ID

MGI:1919224

InterPro

IPR003402 tRNA transferase Trm5/Tyw2
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR025799 Protein arginine N-methyltransferase
IPR027555 tRNA (mo5U34)-methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02475
PF05175
PF06325
PF08241
PF05185
PF08003

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q922H1

PhosphoSite