InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp5

Summary

InnateDB Protein

IDBP-188028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp5

Protein Name

ubiquitin specific peptidase 5 (isopeptidase T)

Synonyms

AA407472; ISOT; ISOT-1; Ucht;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041299

InnateDB Gene

IDBG-188026 (Usp5)

Protein Structure

UniProt Annotation

Function

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0008242	omega peptidase activity
GO:0008270	zinc ion binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1347343

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR001607 Zinc finger, UBP-type
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016652 Ubiquitinyl hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00627
PF00443
PF02148

PRINTS

PIRSF

PIRSF016308

SMART

SM00290
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt