InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itgb7

Summary

InnateDB Protein

IDBP-188079.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgb7

Protein Name

integrin beta 7

Synonyms

Ly69;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001327

InnateDB Gene

IDBG-188077 (Itgb7)

Protein Structure

UniProt Annotation

Function

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0050900	leukocyte migration
GO:0072678	T cell migration

Cellular Component

GO:0008305	integrin complex
GO:0016020	membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96616

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References