InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Marco

Summary

InnateDB Protein

IDBP-188088.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Marco

Protein Name

macrophage receptor with collagenous structure

Synonyms

AI323439; Ly112; Scara2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027639

InnateDB Gene

IDBG-188086 (Marco)

Protein Structure

UniProt Annotation

Function

Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity

Biological Process

GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0043277	apoptotic cell clearance
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005581	collagen trimer
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1309998

InterPro

IPR001190 SRCR domain
IPR008160 Collagen triple helix repeat
IPR017448 SRCR-like domain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00530
PF01391

PRINTS

PR00258

PIRSF

SMART

SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt