InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rarg

Summary

InnateDB Protein

IDBP-188126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rarg

Protein Name

retinoic acid receptor, gamma

Synonyms

Nr1b3; RAR-gamma; RARD; RARgamma2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048838

InnateDB Gene

IDBG-188124 (Rarg)

Protein Structure

UniProt Annotation

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. {ECO:0000250, ECO:0000269PubMed:19389355, ECO:0000269PubMed:8388780}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407, ECO:0000269PubMed:15327771}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	7 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003708	retinoic acid receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0002063	chondrocyte development
GO:0002068	glandular epithelial cell development
GO:0003406	retinal pigment epithelium development
GO:0003417	growth plate cartilage development
GO:0003430	growth plate cartilage chondrocyte growth
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0031076	embryonic camera-type eye development
GO:0031641	regulation of myelination
GO:0032331	negative regulation of chondrocyte differentiation
GO:0032526	response to retinoic acid
GO:0035116	embryonic hindlimb morphogenesis
GO:0035264	multicellular organism growth
GO:0043010	camera-type eye development
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043068	positive regulation of programmed cell death
GO:0043401	steroid hormone mediated signaling pathway
GO:0045596	negative regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048048	embryonic eye morphogenesis
GO:0048384	retinoic acid receptor signaling pathway
GO:0048608	reproductive structure development
GO:0048732	gland development
GO:0060041	retina development in camera-type eye
GO:0060173	limb development
GO:0060324	face development
GO:0060348	bone development
GO:0060349	bone morphogenesis
GO:0060429	epithelium development
GO:0060534	trachea cartilage development
GO:0060740	prostate gland epithelium morphogenesis
GO:0061037	negative regulation of cartilage development
GO:0070384	Harderian gland development
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:97858

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003070 Orphan nuclear receptor
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00545
PR00047
PR00398
PR01284
PR01292

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt