InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: En1

Summary

InnateDB Protein

IDBP-188159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

En1

Protein Name

engrailed 1

Synonyms

En-1; Mo-en.1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078659

InnateDB Gene

IDBG-188157 (En1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0030182	neuron differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0030917	midbrain-hindbrain boundary development
GO:0035115	embryonic forelimb morphogenesis
GO:0035264	multicellular organism growth
GO:0042220	response to cocaine
GO:0043473	pigmentation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048666	neuron development
GO:0060173	limb development

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:95389

InterPro

IPR000104 Antifreeze protein, type I
IPR000747 Homeodomain engrailed
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR019549 Homeobox engrailed, C-terminal
IPR020479 Homeodomain, metazoa

PFAM

PF00046
PF10525

PRINTS

PR00308
PR00026
PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt