InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mei4

Summary

InnateDB Protein

IDBP-188168.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mei4

Protein Name

meiosis-specific, MEI4 homolog (S. cerevisiae)

Synonyms

4930486G11Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061341

InnateDB Gene

IDBG-188166 (Mei4)

Protein Structure

UniProt Annotation

Function

Required for meiotic DNA double-strand break formation. {ECO:0000269PubMed:20551173}.

Subcellular Localization

Chromosome {ECO:0000269PubMed:20551173}. Note=Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages.

Disease Associations

Tissue Specificity

Expressed in adult testis and brain and in embryonic ovary. {ECO:0000269PubMed:20551173}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006310	DNA recombination
GO:0007129	synapsis
GO:0007283	spermatogenesis
GO:0042138	meiotic DNA double-strand break formation
GO:0048477	oogenesis

Cellular Component

GO:0000800

lateral element

Protein Structure and Domains

PDB ID

MGI:1922283

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BRM6

PhosphoSite

PhosphoSite-Q8BRM6

TrEMBL

UniProt Splice Variant

Entrez Gene

75033

UniGene

Mm.335329

RefSeq

NP_780422

MGI ID

MGI Symbol

Mei4

OMIM

CCDS

CCDS23371

HPRD

IMGT

EMBL

AC122931 AC132430 AK043929 AK082395 BC096613

GenPept

AAH96613 BAC31705 BAC38486