Mus musculus Protein: Nell1
Summary
InnateDB Protein IDBP-188189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nell1
Protein Name NEL-like 1 (chicken)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000080550
InnateDB Gene IDBG-188187 (Nell1)
Protein Structure
UniProt Annotation
Function Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. {ECO:0000269PubMed:16537572}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus envelope {ECO:0000250}. Secreted {ECO:0000250}. Note=Colocalizes with ATRAID on the nuclear envelope and the perinuclear region. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0010468 regulation of gene expression
GO:0030154 cell differentiation
GO:0030501 positive regulation of bone mineralization
GO:0033689 negative regulation of osteoblast proliferation
GO:0045669 positive regulation of osteoblast differentiation
GO:2000599 negative regulation of cyclin catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2443902
InterPro IPR000742 Epidermal growth factor-like domain
IPR001007 von Willebrand factor, type C
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR006552 VWC out
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00008
PF00093
PF00054
PF02210
PF07645
PRINTS
PIRSF
SMART SM00181
SM00214
SM00210
SM00282
SM00179
SM00215
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2VWQ2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 338352
UniGene Mm.410076
RefSeq NP_001032995
MGI ID
MGI Symbol Nell1
OMIM
CCDS CCDS21309
HPRD
IMGT
EMBL AY622226
GenPept AAV41488