InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Espl1

Summary

InnateDB Protein

IDBP-188240.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Espl1

Protein Name

extra spindle poles-like 1 (S. cerevisiae)

Synonyms

AL024103; AU045071; Cerp; ESP1; PRCE; SSE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064465

InnateDB Gene

IDBG-188238 (Espl1)

Protein Structure

UniProt Annotation

Function

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000212	meiotic spindle organization
GO:0006508	proteolysis
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007127	meiosis I
GO:0045143	homologous chromosome segregation