Version 5.4
Mus musculus Protein: Leprel2
Summary
InnateDB Protein IDBP-188248.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Leprel2
Protein Name leprecan-like 2
Synonyms BC016431; Grcb; P3h3;
Species Mus musculus
Ensembl Protein ENSMUSP00000023958
InnateDB Gene IDBG-188246 (Leprel2)
Protein Structure
UniProt Annotation
Function Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum {ECO:0000255PROSITE- ProRule:PRU10138}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019797 procollagen-proline 3-dioxygenase activity
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0019511 peptidyl-proline hydroxylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005575 cellular_component
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID MGI:1315208
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
PFAM
PRINTS
PIRSF
SMART SM00702
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CG70
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 14789
UniGene Mm.35708
RefSeq NP_038562
MGI ID
MGI Symbol Leprel2
OMIM
CCDS CCDS20533
HPRD
IMGT
EMBL AC002397 AJ441086 AY463530 BC003726 BC016431
GenPept AAC36012 AAH03726 AAH16431 AAS45239 CAD29580

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca