InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mgat4c

Summary

InnateDB Protein

IDBP-188311.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgat4c

Protein Name

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)

Synonyms

9130411I17Rik; GntIVh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020039

InnateDB Gene

IDBG-188309 (Mgat4c)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1- 4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0046872	metal ion binding