Version 5.4
Mus musculus Protein: Ano5
Summary
InnateDB Protein IDBP-188332.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ano5
Protein Name anoctamin 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000046884
InnateDB Gene IDBG-188330 (Ano5)
Protein Structure
UniProt Annotation
Function Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:17418107}; Multi-pass membrane protein {ECO:0000269PubMed:17418107}. Cell membrane {ECO:0000269PubMed:17418107}. Note=Colocalized with CALR/calreticulin. Shows an intracellular localization (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle, bone tissues and thyroid gland. {ECO:0000269PubMed:15124103, ECO:0000269PubMed:15882990, ECO:0000269PubMed:17418107, ECO:0000269PubMed:20056604}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031982 vesicle
Protein Structure and Domains
PDB ID MGI:3576659
InterPro IPR007632 Anoctamin
PFAM PF04547
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q75UR0
PhosphoSite PhosphoSite-Q75UR0
TrEMBL
UniProt Splice Variant
Entrez Gene 233246
UniGene Mm.411727
RefSeq NP_808362
MGI ID
MGI Symbol Ano5
OMIM
CCDS CCDS39968
HPRD
IMGT
EMBL AB125740 AB206762 AK034197 BC109163
GenPept AAI09164 BAC28628 BAD17873 BAE44438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca