InnateDB Protein
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IDBP-18836.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FBXO4
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Protein Name
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F-box protein 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000281623
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InnateDB Gene
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IDBG-18832 (FBXO4)
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Protein Structure
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Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. {ECO:0000269PubMed:10531035, ECO:0000269PubMed:16275645, ECO:0000269PubMed:18598945, ECO:0000269PubMed:20159592, ECO:0000269PubMed:20181953}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0000209
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protein polyubiquitination
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GO:0000723
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telomere maintenance
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0016567
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protein ubiquitination
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GO:0031146
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SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0031398
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positive regulation of protein ubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR001810
F-box domain
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PFAM |
PF00646
PF12937
PF13013
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PRINTS |
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PIRSF |
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SMART |
SM00256
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UKT5
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PhosphoSite |
PhosphoSite-Q9UKT5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26272
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UniGene |
Hs.604913
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RefSeq |
NP_036308
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HUGO |
HGNC:13583
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OMIM |
609090
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CCDS |
CCDS3938
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HPRD |
09949
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IMGT |
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EMBL |
AF129534
AF176703
BC048098
CR749719
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GenPept |
AAF03703
AAF04468
AAH48098
CAH18486
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