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InnateDB Protein
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IDBP-188382.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ptcra
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Protein Name
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pre T-cell antigen receptor alpha
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Synonyms
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gp33; pT-alpha; pT-alpha-TCR; pT[a]; pTa; pTalpha;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000035683
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InnateDB Gene
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IDBG-188380 (Ptcra)
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Protein Structure
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| Function |
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3-TCRB complex. {ECO:0000269PubMed:9647201}.
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| Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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| Disease Associations |
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| Tissue Specificity |
Isoform 1 is expressed at higher levels than isoform 2 in the thymus while only isoform 2 is expressed in polyclonal beta-only cells. Isoform 1 shows a predominant expression in immature thymocytes. {ECO:0000269PubMed:7973703, ECO:0000269PubMed:9647201}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
5 [view]
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Molecular Function |
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| Biological Process |
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GO:0070244
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negative regulation of thymocyte apoptotic process
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| Cellular Component |
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| PDB ID |
MGI:104857
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
P0C6B2
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
19208
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| UniGene |
Mm.215173
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| RefSeq |
NP_035325
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| MGI ID |
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| MGI Symbol |
Ptcra
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC119062
BC120746
U16958
U27268
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| GenPept |
AAA58963
AAA84398
AAI19063
AAI20747
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Version 5.4