InnateDB Protein
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IDBP-188432.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Adprhl2
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Protein Name
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ADP-ribosylhydrolase like 2
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Synonyms
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AI836109; Arh3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099677
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InnateDB Gene
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IDBG-188430 (Adprhl2)
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Protein Structure
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Function |
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16278211}. Mitochondrion matrix {ECO:0000250}. Nucleus {ECO:0000269PubMed:16278211}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:16278211}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2140364
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InterPro |
IPR005502
ADP-ribosylation/Crystallin J1
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PFAM |
PF03747
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CG72
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
100206
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UniGene |
Mm.11285
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RefSeq |
NP_598644
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MGI ID |
2QTY
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MGI Symbol |
Adprhl2
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OMIM |
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CCDS |
CCDS18650
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HPRD |
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IMGT |
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EMBL |
AJ427296
AK143583
AK147034
AK169070
AK171780
AL606976
BC010639
BC023177
BC045203
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GenPept |
AAH10639
AAH23177
AAH45203
BAE25451
BAE27626
BAE40857
BAE42660
CAD20317
CAM45877
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