InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx18

Summary

InnateDB Protein

IDBP-188437.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx18

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 18

Synonyms

2310005B10Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001724

InnateDB Gene

IDBG-188435 (Ddx18)

Protein Structure

UniProt Annotation

Function

Probable RNA-dependent helicase.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0008150	biological_process

Cellular Component

GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1914192

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K363