Version 5.4
Mus musculus Protein: Gpr183
Summary
InnateDB Protein IDBP-188487.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpr183
Protein Name G protein-coupled receptor 183
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000052404
InnateDB Gene IDBG-188485 (Gpr183)
Protein Structure
UniProt Annotation
Function Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2). {ECO:0000250, ECO:0000269PubMed:19597478, ECO:0000269PubMed:19615922, ECO:0000269PubMed:21673108}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in mature B-cells and increases in expression early after activation, before being down-regulated in germinal center B-cells. {ECO:0000269PubMed:19597478}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008142 oxysterol binding
Biological Process
GO:0002313 mature B cell differentiation involved in immune response
GO:0006959 humoral immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0030890 positive regulation of B cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2442034
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR009150 Neuropeptide B/W receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10328
PRINTS PR00237
PR01855
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U6B2
PhosphoSite PhosphoSite-Q3U6B2
TrEMBL
UniProt Splice Variant
Entrez Gene 321019
UniGene Mm.265618
RefSeq NP_898852
MGI ID
MGI Symbol Gpr183
OMIM
CCDS CCDS27343
HPRD
IMGT
EMBL AK138693 AK153216 AK156005 AY255606 BC052868
GenPept AAH52868 AAO85118 BAE23750 BAE31813 BAE33542

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca