Version 5.4
Homo sapiens Protein: DCUN1D3
Summary
InnateDB Protein IDBP-18861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCUN1D3
Protein Name DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000319482
InnateDB Gene IDBG-18859 (DCUN1D3)
Protein Structure
UniProt Annotation
Function Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8- conjugating E2 enzyme UBE2F. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. {ECO:0000269PubMed:23201271}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0010225 response to UV-C
GO:0010332 response to gamma radiation
GO:0030308 negative regulation of cell growth
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR005176 Potentiating neddylation domain
PFAM PF03556
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IWE4
PhosphoSite PhosphoSite-Q8IWE4
TrEMBL
UniProt Splice Variant
Entrez Gene 123879
UniGene Hs.702523
RefSeq NP_775746
HUGO HGNC:28734
OMIM
CCDS CCDS10592
HPRD 14660
IMGT
EMBL AK123719 AY364247 BC040442 CH471228
GenPept AAH40442 AAQ76806 BAG53946 EAW66842

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca